Protocadherin 15 (PCDH15): a new secreted isoform and a potential marker for NK/T cell lymphomas.
Oncogene
; 25(19): 2807-11, 2006 May 04.
Article
en En
| MEDLINE
| ID: mdl-16369489
ABSTRACT
Natural killer cells are well known to play an important role in immune defense against tumor development and viral infections. To further characterize new functionally relevant structures in these cells, we studied a series of monoclonal antibodies that we have raised against the NK cell line YT. One of these antibodies previously described as AY19, recognizes a 85 kD surface glycoprotein. Here we report the identification of a new secreted isoform of protocadherin 15, PCDH15C, which represents a potential associated protein for p85. Importantly, whereas protocadherins are absent from the surface of normal hematopoietic cells, we describe, for the first time, that PCDH15 is expressed in cytotoxic tumor-derived T- and NK-cell lines as well as in biopsies of nasal NK/T-cell lymphomas.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Precursores de Proteínas
/
Células Asesinas Naturales
/
Biomarcadores de Tumor
/
Cadherinas
/
Neoplasias Nasales
/
Linfoma de Células T
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Oncogene
Asunto de la revista:
BIOLOGIA MOLECULAR
/
NEOPLASIAS
Año:
2006
Tipo del documento:
Article
País de afiliación:
Francia