Your browser doesn't support javascript.
loading
Burn-induced alterations of chromium and the glucose/insulin system in rats.
Anderson, Richard A; Sandre, Caroline; Bryden, Noella A; Agay, Diane; Chancerelle, Yves; Polansky, Marilyn M; Roussel, Anne-Marie.
Afiliación
  • Anderson RA; Nutrient Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, Agriculture Research Service, United States Department of Agriculture, Beltsville, MD 20705, USA. AndersonR@ba.ars.usda.gov
Burns ; 32(1): 46-51, 2006 Feb.
Article en En | MEDLINE | ID: mdl-16384652
ABSTRACT
Our objective was to demonstrate a role of chromium (Cr) in response to severe burn. A third-degree burn involving 20% of total body surface was applied under anaesthesia in accord with ethical guidelines. Chromium concentrations in liver decreased progressively and were non-detectable on days 5 and 10 following injury. In quadriceps muscle, Cr concentrations increased 6h after injury and then declined significantly within the first day and remained at these levels the following 9 days. Urinary Cr losses were also increased. Changes in kidney, brain and serum Cr were not significant. Non-fasting glucose rose 6h after injury and then returned to levels measured before the burn. There was a significant rise in corticosterone reaching a maximum the first day after injury that was accompanied by significant increases in circulating insulin and glucagon that were maximal after 2 days. Changes in IGF-1 were not significant. In summary, changes in Cr concentrations were associated with an early hyperglycemia, hyperinsulinemia and increased secretion of stress hormones. These observations strongly suggest a mobilization and utilization of Cr following severe burn. Additional studies are needed to document that improved Cr status might lead to improved recovery following burn.
Asunto(s)
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Quemaduras / Cromo / Insulina Tipo de estudio: Etiology_studies Aspecto: Ethics Límite: Animals Idioma: En Revista: Burns Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Quemaduras / Cromo / Insulina Tipo de estudio: Etiology_studies Aspecto: Ethics Límite: Animals Idioma: En Revista: Burns Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos