Neonatal screening for congenital cytomegalovirus infection and hearing loss.
J Clin Virol
; 35(2): 206-9, 2006 Feb.
Article
en En
| MEDLINE
| ID: mdl-16384745
ABSTRACT
BACKGROUND:
Congenital cytomegalovirus infection causes 20-30% of congenital sensorineural hearing loss (SNHL) cases. Early identification of CMV attributable cases and their successful treatment are often hampered by the late appearance of the damage in a high proportion of children both symptomatic and asymptomatic at birth.OBJECTIVE:
To discuss the feasibility of a screening program aimed at finding congenitally infected babies followed by their audiological monitoring. STUDYDESIGN:
Opinion-review article. RESULTS ANDCONCLUSIONS:
Frequency and severity of hearing loss due to congenital CMV suggest it maybe worthwhile setting up neonatal screening campaigns. Structures where SNHL can be diagnosed and treated exist already in many countries as part of universal neonatal audiological screening schemes. A test based on viral DNA extraction from neonatal dried blood spots on Guthrie cards and its amplification by means of a nested PCR (DBS test) seems to offer the best characteristics for use in screening. Clearly it will be necessary to calculate whether the costs of screening, diagnosis and follow-up, and the financial and emotional burden on the families of infected children, are up to the potential gain.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Citomegalovirus
/
Citomegalovirus
/
Pérdida Auditiva Sensorineural
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Límite:
Humans
/
Infant
/
Newborn
Idioma:
En
Revista:
J Clin Virol
Asunto de la revista:
VIROLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Italia