Eprinomectin in dairy zebu Gobra cattle (Bos indicus): plasma kinetics and excretion in milk.
Parasitol Res
; 98(6): 501-6, 2006 May.
Article
en En
| MEDLINE
| ID: mdl-16416124
ABSTRACT
The pharmacokinetics and mammary excretion of eprinomectin were determined in zebu Gobra following topical administration of 0.5 mg kg(-1). The kinetics of plasma and milk was analysed using a one-compartment model. The maximum plasma concentration of 8.83+/-2.15 ng ml(-1) occurred 1.30 days post-administration. The area under the plasma concentration-time curve was 30.63+/-5.56 ng day(-1) ml(-1) and the mean residence time was 3.38+/-0.60 days. Eprinomectin was detected in milk at the first sampling time and thereafter for at least 8 days. The systemic availability of eprinomectin was significantly lower than that for other breeds of cattle. Comparison of the milk and plasma data demonstrated the parallel disposition of the drug in the milk and plasma with a milk/plasma ratio of 0.094. The very low extent of mammary excretion supports the permitted use of eprinomectin in lactating zebu Gobra.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ivermectina
/
Bovinos
/
Leche
/
Antihelmínticos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Parasitol Res
Asunto de la revista:
PARASITOLOGIA
Año:
2006
Tipo del documento:
Article