68Zn isotope exchange experiments reveal an unusual kinetic lability of the metal ions in the di-zinc form of IMP-1 metallo-beta-lactamase.
Chem Commun (Camb)
; (5): 532-4, 2006 Feb 07.
Article
en En
| MEDLINE
| ID: mdl-16432573
ABSTRACT
The apparently paradoxical behaviour of facile exchange (kinetic lability) of tightly bound (thermodynamic stability) zinc ions in the enzyme IMP-1 metallo-beta-lactamase with Zn-68 and cadmium ions, as indicated by in-torch vaporization inductively-coupled plasma mass spectrometry (ITV-ICP-MS) and electrospray-ionization mass spectrometry (ESI-MS), is consistent with the involvement of a third metal ion in promoting Lewis acid/base type exchange processes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Zinc
/
Isótopos de Zinc
/
Beta-Lactamasas
/
Cadmio
Idioma:
En
Revista:
Chem Commun (Camb)
Asunto de la revista:
QUIMICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Canadá