Highly N-methylated linear peptides produced by an atypical sponge-derived Acremonium sp.
J Nat Prod
; 69(1): 83-92, 2006 Jan.
Article
en En
| MEDLINE
| ID: mdl-16441074
ABSTRACT
RHM1 (1) and RHM2 (2) are highly N-methylated linear octapeptides produced by an atypical strain of Acremonium sp., cultured from a marine sponge collected in Papua New Guinea. The known peptaibiotic efrapeptin G (3) was also isolated from this fungus. The planar structures of 1 and 2 were assigned based on 1D- and 2D-NMR experiments and fragmentation patterns from ESIMS. The absolute configuration of 1 was determined via Marfey's method; the absolute configuration of 2 is proposed to be identical. Efrapeptin G (3) displayed potent cytotoxicity against murine cancer cell lines, while RHM1 (1) and RHM2 (2) showed weak cytotoxicity against murine cancer cell lines; efrapeptin G (3) and RHM1 (1) also demonstrated antibacterial activity.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Acremonium
/
Antineoplásicos
Límite:
Animals
Idioma:
En
Revista:
J Nat Prod
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos