Common alterations in the serotonin transporter in platelets and lymphocytes of psychotic patients.
Pharmacopsychiatry
; 39(1): 35-8, 2006 Jan.
Article
en En
| MEDLINE
| ID: mdl-16453253
ABSTRACT
INTRODUCTION:
Given the controversial data concerning the role of the serotonin (5-HT) transporter in psychosis, our study was aimed to investigate this structure by means of the measurements of the re-uptake kinetics and of the protein density, in both platelets and lymphocytes of 25 out- and inpatients with different psychotic disorders.METHODS:
Diagnoses, according to DSM-IV criteria, were bipolar 1 disorders with mood incongruent psychotic features (14), mixed states (7) and schizophrenia (4). Twenty-five matched healthy subjects were also selected as the control group. Platelet and lymphocyte membranes were prepared according to standardized protocols, as were the [3H]5HT re-uptake and [3H]paroxetine ([3H]Par) binding.RESULTS:
The results of this study showed a decreased density of the [3H]Par binding sites coupled with a reduced velocity of [3H]5-HT re-uptake in both platelets and lymphocytes of psychotic patients, as compared with healthy control subjects.CONCLUSION:
These findings would suggest a general abnormality of the 5-HT system in psychotic patients, probably not confined only to the brain.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trastornos Psicóticos
/
Plaquetas
/
Linfocitos
/
Proteínas de Transporte de Serotonina en la Membrana Plasmática
Tipo de estudio:
Guideline
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Pharmacopsychiatry
Año:
2006
Tipo del documento:
Article
País de afiliación:
Italia