[Nanotechnology for therapy of type 2 diabetes].
Nihon Rinsho
; 64(2): 295-300, 2006 Feb.
Article
en Ja
| MEDLINE
| ID: mdl-16454184
ABSTRACT
All-trans Retinoic Acid (atRA), is known as a member of retinoid, and the atRA nano-particle with coated by CaCO3 (nanoegg -atRA), was recently developed as a new drug delivery system (DDS). This nanoparticles stimulated insulin secretion from islets in a glucose-dependent manner at streptozotocin (STZ)-induced diabetes. The stains on pancreas of Wistar rat at STZ induced diabetes, which was subcutaneous administered nanoegg -atRA 6 mg/head/week for 141 days, showed not only the expression of PDX-1 but also the presence of beta cell in islet of Langerhans. Furthermore, the increase of insulin concentration in plasma was also observed. Our data indicate that nanoegg -atRA might contribute to the regeneration of beta cells in vivo, and provide useful information for future therapy of diabetes mellitus.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tretinoina
/
Islotes Pancreáticos
/
Nanoestructuras
/
Diabetes Mellitus Tipo 2
/
Insulina
Límite:
Animals
Idioma:
Ja
Revista:
Nihon Rinsho
Año:
2006
Tipo del documento:
Article