Allelic variation of a functional polymorphism in the serotonin transporter gene and depression in Parkinson's disease.
Parkinsonism Relat Disord
; 12(3): 139-41, 2006 Apr.
Article
en En
| MEDLINE
| ID: mdl-16459126
ABSTRACT
A genetic susceptibility to depression in PD, acting via the serotonergic system, has been suggested. We examined the influence of allelic variation (L/S) in a functional polymorphism in the serotonin transporter (5-HTTLPR) gene upon mood in 108 PD patients and 82 controls. Using a logistic regression model we found no evidence for an association between 5-HTTLPR genotypes, or the presence of the S allele, and depression.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Polimorfismo Genético
/
Depresión
/
Proteínas de Transporte de Serotonina en la Membrana Plasmática
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Parkinsonism Relat Disord
Asunto de la revista:
NEUROLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Reino Unido