Serum alpha-tocopherol concentrations and risk of type 1 diabetes mellitus: a cohort study in siblings of affected children.
J Pediatr Endocrinol Metab
; 18(12): 1409-16, 2005 Dec.
Article
en En
| MEDLINE
| ID: mdl-16459467
ABSTRACT
Animal models have indicated that alpha-tocopherol may protect against type 1 diabetes mellitus (DM1). Epidemiological data on the subject are scarce. The objective of this study was to evaluate the association of serum alpha-tocopherol concentration and risk of DM1 in a cohort of initially non-diabetic siblings of children affected by DM1 (n = 722). We used two study designs 1) Siblings who progressed to DM1 were compared with control siblings who remained negative for DM1-associated autoantibodies in a nested case-control study design. 2) All siblings with DM1-associated autoantibodies were prospectively followed for DM1. In both designs, high concentrations of serum alpha-tocopherol tended to be associated with a lower risk of DM1 (p = 0.08 and 0.09, respectively). Although the results did not reach statistical significance, they support the hypothesis that high alpha-tocopherol levels may protect against DM1.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Alfa-Tocoferol
/
Hermanos
/
Diabetes Mellitus Tipo 1
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
/
Newborn
Idioma:
En
Revista:
J Pediatr Endocrinol Metab
Asunto de la revista:
ENDOCRINOLOGIA
/
PEDIATRIA
Año:
2005
Tipo del documento:
Article
País de afiliación:
Finlandia
Pais de publicación:
ALEMANHA
/
ALEMANIA
/
DE
/
DEUSTCHLAND
/
GERMANY