Translational regulators maintain totipotency in the Caenorhabditis elegans germline.
Science
; 311(5762): 851-3, 2006 Feb 10.
Article
en En
| MEDLINE
| ID: mdl-16469927
ABSTRACT
The molecular mechanisms that maintain totipotency of the germline are not well understood. Here, we show that two conserved translational regulators, MEX-3 and GLD-1, are essential for maintaining totipotency in the Caenorhabditis elegans germline. In mex-3 gld-1 mutants, germ cells transdifferentiate into various somatic cell types such as muscles or neurons. Our findings implicate RNA regulation in the maintenance of totipotency, suggest that multiple mechanisms maintain totipotency at different stages of germline development, and establish a genetically tractable model for studying the development of teratomas.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Unión al ARN
/
Caenorhabditis elegans
/
Proteínas de Caenorhabditis elegans
/
Células Germinativas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos