Anti-adhesion properties of a thrombin-based hemostatic gelatin in a canine laminectomy model: a biomechanical, biochemical, and histologic study.
Spine (Phila Pa 1976)
; 31(4): E91-7, 2006 Feb 15.
Article
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| MEDLINE
| ID: mdl-16481942
ABSTRACT
STUDY DESIGN:
An in vivo study on the effects of an agent for scar prevention in a dog laminectomy model.OBJECTIVE:
To examine the anti-adhesion properties of a thrombin-based hemostatic gelatin (FLOSEAL; Baxter International Inc., Deerfield, IL). SUMMARY OF BACKGROUND DATA Postlaminectomy dural adhesion sometimes causes symptomatic problems. Although a new type of hemostatic agent, a thrombin-based hemostatic gelatin, has been developed, its effect on postlaminectomy scar prevention is unknown.METHODS:
A 4-level lumbar laminectomy was performed on 11 adult mongrel dogs. There were 2 levels randomly chosen to receive the thrombin-based hemostatic gelatin treatment, while the remaining levels were untreated (control). Dogs were euthanized 8 weeks after surgery. To assess the tenacity of adhesion between the dura and scar, peel-off testing was performed. Gross, biochemical, and histologic analyses were then used to examine the samples.RESULTS:
Peel-off stiffness was significantly decreased in the treatment group (64.8% of the control, P = 0.032; 2-tailed unpaired t test). Histologically, there was significantly less scar tissue formation in the treatment group (P = 0.04). The gross analyses showed a trend toward a smaller amount of scar tissue and tenacity of adhesion between the dura and scar in the treatment group. Biochemically, there was a trend toward a lower collagen cross-links content in the treatment group (P = 0.07).CONCLUSIONS:
The thrombin-based hemostatic gelatin decreases the tenacity of adhesion between the dura and scar at laminectomy sites.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hemostáticos
/
Trombina
/
Adherencias Tisulares
/
Cicatriz
/
Esponja de Gelatina Absorbible
/
Laminectomía
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Spine (Phila Pa 1976)
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos