[Effect of silodosin on intraurethral pressure increase induced by hypogastric nerve stimulation in dogs with benign prostatic hyperplasia].
Yakugaku Zasshi
; 126 Spec no.: 225-30, 2006 Mar.
Article
en Ja
| MEDLINE
| ID: mdl-16518087
ABSTRACT
We compared the urethral and cardiovascular effects of silodosin (selective alpha(1A)-adrenoceptor antagonist), a novel medication for benign prostatic hyperplasia (BPH), with those of tamsulosin (selective alpha(1A)/alpha(1D)-adrenoceptor antagonist) and naftopidil (selective alpha(1D)-adrenoceptor antagonist). We evaluated the effects of these three drugs on the increase in intraurethral pressure (IUP) induced by electrical stimulation of the hypogastric nerve in anesthetized dogs with spontaneous BPH. All three drugs dose-dependently reduced both the increase in IUP and the mean blood pressure (MBP). The rank order of potencies was tamsulosin>silodosin>naftopidil for the reductions in both IUP and MBP. However, the uroselectivity (ED(15) value for hypotensive effect/ID(50) value for reduction in IUP) of silodosin (uroselectivity, 19.8) was about 21 and 4 times higher than that of tamsulosin (0.939) and naftopidil (4.94), respectively. These data suggest that silodosin might be one of the most useful medications for dysuria in BPH patients.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Presión
/
Hiperplasia Prostática
/
Uretra
/
Antagonistas Adrenérgicos alfa
/
Antagonistas de Receptores Adrenérgicos alfa 1
/
Plexo Hipogástrico
/
Indoles
Límite:
Animals
Idioma:
Ja
Revista:
Yakugaku Zasshi
Año:
2006
Tipo del documento:
Article
País de afiliación:
Japón