An improved asymmetric reformatsky reaction mediated by (-)-N,N-dimethylaminoisoborneol.

Kloetzing, Ralf J; Thaler, Tobias; Knochel, Paul

Kloetzing, Ralf J; Thaler, Tobias; Knochel, Paul.

Afiliación

Kloetzing RJ; Department of Chemistry and Biochemistry, Ludwig-Maximilians-University, Butenandtstrasse 5-13, 81377 Munich, Germany.

Org Lett ; 8(6): 1125-8, 2006 Mar 16.

Article en En | MEDLINE | ID: mdl-16524284

ABSTRACT

ABSTRACT

[reaction see text] (-)-N,N-Dimethylaminoisoborneol ((-)-DAIB) was found to be an excellent ligand for the enantioselective addition of Reformatsky reagents to aromatic and aliphatic aldehydes. Enantioselectivities up to 93% ee were obtained with sulfur-containing aldehydes.

Asunto(s)

Canfanos/química; Aldehídos/química; Catálisis; Ligandos; Estructura Molecular; Estereoisomerismo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canfanos Idioma: En Revista: Org Lett Asunto de la revista: BIOQUIMICA Año: 2006 Tipo del documento: Article País de afiliación: Alemania

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