[Acetylsalicylic acid does not alter the mechanoelectrical transduction of mammalian outer hair cells in vitro]. / Die mechanoelektrische Transduktion der äusseren Haarzelle wird durch Azetylsalizylsäure in vitro nicht beeinflusst.
HNO
; 54(9): 670-6, 2006 Sep.
Article
en De
| MEDLINE
| ID: mdl-16528510
ABSTRACT
BACKGROUND:
High doses of acetylsalicylic acid (ASS) induce tinnitus and hearing loss. This ototoxic side effect of ASS is characterized by a decrease in spontaneous and evoked otoacoustic emissions. A decrease in otoacoustic emissions is found not only in mammals, but also in non-mammalian ears without electromotile outer hair cells. The molecular mechanism underlying ASS ototoxicity seems to be competitive binding to and a block of the motor molecule prestin. In non-mammalian species, ASS ototoxicity is possibly explained by an effect on the hair bundle.RESULTS:
The present data from the outer hair cells of the adult guinea pig cochlea show a reduction in the membrane capacitance by maximally 42%, probably as a result of ASS binding competitively to the motor molecule. However, spontaneous and evoked receptor currents were not modulated by ASS.CONCLUSION:
The results suggest an influence of ASS on outer hair cell somatic electromotility, without a concomitant effect on hair-bundle function.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aspirina
/
Células Ciliadas Auditivas Externas
/
Mecanotransducción Celular
/
Potenciales Evocados Auditivos
/
Potenciales de la Membrana
Límite:
Animals
Idioma:
De
Revista:
HNO
Año:
2006
Tipo del documento:
Article