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[Blood viscosity profile in rapidly progressive sensorineural hearing loss with positive Western-blot]. / Perfil de la viscosidad sanguínea en la hipoacusia rápidamente progresiva con Western-blot positivo.
García Callejo, F J; De Paula Vernetta, C; Platero Zamarreño, A; Orts, Alborch M H; Velert Vila, M M; Morera Pérez, C; Marco Algarra, J.
Afiliación
  • García Callejo FJ; Servicio de ORL, Hospital Clínico Universitario, Valencia. jgarciacall@hotmail.com
Acta Otorrinolaringol Esp ; 57(2): 90-5, 2006 Feb.
Article en Es | MEDLINE | ID: mdl-16550861
OBJECTIVE: To value a possible association between disorders in blood viscosity of patients with rapidly progressive sensorineural hearing loss (RPSHL) of autoimmune origin. PATIENTS AND METHODS: We studied the viscoelastic properties of blood in 43 subjects bearing of RPSHL and a positive Western-blot for anticochlear antibodies: whole blood viscosity (WBV) at different shear rates and erythrocyte filterability (EF). These results were related to hearing loss initially detected and recovery average one year later from steroid therapy. RESULTS: Just WBV at 230 sec(-1) shear rate was significatively higher in cases than in controls (p < 0.01). Hearing recovery degree correlated in an statistically way to increased values of EF (p < 0.01). There was no relation between initial hearing loss level and any rheology parameter. CONCLUSIONS: Autoimmune RPSHL does not show a pathophysiology mechanism associated to blood hyperviscosity. So, rheoactive therapies as plasmapheresis warrant no clinical improvement.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Viscosidad Sanguínea / Western Blotting / Anticuerpos Antinucleares / Pérdida Auditiva Sensorineural Límite: Adult / Female / Humans / Male Idioma: Es Revista: Acta Otorrinolaringol Esp Año: 2006 Tipo del documento: Article Pais de publicación: España
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Viscosidad Sanguínea / Western Blotting / Anticuerpos Antinucleares / Pérdida Auditiva Sensorineural Límite: Adult / Female / Humans / Male Idioma: Es Revista: Acta Otorrinolaringol Esp Año: 2006 Tipo del documento: Article Pais de publicación: España