Effect of two flavonoid compounds on central nervous system. Analgesic activity.
Life Sci
; 49(26): 1979-88, 1991.
Article
en En
| MEDLINE
| ID: mdl-1660953
ABSTRACT
The psychopharmacological profile of quercetin (Q) and penta-O-ethylquercetin (PQ) showed for both compounds a sedative effect on central nervous system in mice. In this set of pharmacological tests (hypothermia, spontaneous motility, psychomotor activity) penta-O-ethylquercetin always exerted a more pronounced effect than quercetin, probably due to the difference of lipophilicity. In analgesia experiments such as acetic acid-induced writhings, penta-O-ethylquercetin showed a significant dose-related effect whereas quercetin was inactive. As pretreatment with naloxone failed to antagonize the analgesic activity of penta-O-ethylquercetin, it was suggested that penta-O-ethylquercetin acted mainly peripherally.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Quercetina
/
Sistema Nervioso Central
/
Analgésicos
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Life Sci
Año:
1991
Tipo del documento:
Article
País de afiliación:
Francia