High prevalence of morphological subtype FAB M1 in adults with de novo acute myeloid leukemia in São José dos Campos, São Paulo.
Sao Paulo Med J
; 124(1): 45-7, 2006 Jan 05.
Article
en En
| MEDLINE
| ID: mdl-16612463
ABSTRACT
CONTEXT AND OBJECTIVE:
Geographical variations have been described in acute myelogenous leukemia (AML). In Brazil, few studies have been published on this. The aim of this study was to demonstrate the high prevalence of French-American-British (FAB) M1 subtype in adults with de novo AML in São José dos Campos, State of São Paulo, Brazil. DESIGN ANDSETTING:
Retrospective analysis, at Hospital Pio XII in São José dos Campos, a public non-teaching institution.METHODS:
Records from 39 consecutive adult patients with de novo AML referred to Hospital Pio XII between January 2002 and September 2004 were reviewed. Peripheral blood and blood marrow smears were reviewed blindly by five hematologists and classified according to FAB criteria. The rates of remission, relapse, mortality according treatment phase, survival and leukemia-free survival were calculated.RESULTS:
The prevalence of each category as determined via a consensus among five observers was M0 0%; M1 43.6%; M2 30.7%; M3 12.8%; M4 5.1%; M5 2.6% M6 2.6%; and M7 2.6%. The remission and the relapse rates were 82% and 41% respectively. The mortality rate was 69% (induction of remission 7/39, 17.9%; post induction 10/32, 31.2%; and relapse 10/16, 62.5%). The survival rate was 30% and leukemia-free survival was 33%.CONCLUSIONS:
The study demonstrated a high prevalence of FAB M1 subtype in adults with de novo AML in São José dos Campos. Our data suggest the occurrence of different regional prevalences of FAB AML categories in Brazil.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucemia Mieloide Aguda
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Sao Paulo Med J
Asunto de la revista:
MEDICINA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Brasil