Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae.
Vaccine
; 24(22): 4804-11, 2006 May 29.
Article
en En
| MEDLINE
| ID: mdl-16616975
ABSTRACT
Passive transfer of a pediatric human serum pool generated against polysaccharide-protein D conjugate vaccines conferred approximately 34% protection against development of ascending NTHI-induced OM when used in a chinchilla viral-bacterial co-infection model. These data are in line with results obtained using a similar 11-valent-protein D conjugate vaccine in a pediatric clinical trial, wherein a vaccine efficacy of 35.6% was shown against acute OM episodes caused by NTHI. These observations strongly support the chinchilla passive transfer-superinfection model as one that could predict clinical trials outcomes for vaccines to prevent NTHI-induced OM.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Otitis Media
/
Polisacáridos Bacterianos
/
Proteínas Bacterianas
/
Inmunoglobulina D
/
Proteínas Portadoras
/
Haemophilus influenzae
/
Inmunización Pasiva
/
Vacunas contra Haemophilus
/
Lipoproteínas
/
Anticuerpos Antibacterianos
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Vaccine
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos