Novel valproic acid derivatives with hemoglobin F inducing activity.
Am J Hematol
; 81(5): 374-6, 2006 May.
Article
en En
| MEDLINE
| ID: mdl-16628726
ABSTRACT
Pharmacological induction of hemoglobin F expression may be a promising approach for the treatment of beta-thalassemia and sickle cell disease. Valproic acid, a drug frequently used for the treatment of seizure disorders, has been shown to enhance fetal hemoglobin synthesis in erythroid cells. However, this effect is only modest and requires relative high concentrations. Therefore, the drug appears not to be applicable for the treatment of beta-globin chain disorders. Here, we describe the identification of novel valproic acid derivatives with potent hemoglobin F inducing activities at concentrations that presumably can be obtained in vivo.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hemoglobina Fetal
/
Ácido Valproico
Límite:
Humans
Idioma:
En
Revista:
Am J Hematol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Alemania