The basis for treatment in multiple sclerosis.
Acta Neurol Scand Suppl
; 183: 41-7, 2006.
Article
en En
| MEDLINE
| ID: mdl-16637928
ABSTRACT
Contemporary licensed treatments for multiple sclerosis fail to provide a solution for the disease because their effects are limited to a modest reduction in the frequency of new episodes. They do not reduce disability or materially influence the progressive phase of the disease. A contemporary strategy for management requires a more detailed analysis of the separate contributions to the clinical features and overall course made by inflammation, axonal injury, compensatory mechanisms, and remyelination. From this formulation emerges the need either for early and fully effective suppression of the inflammatory response, limiting the damage to all components of the axon-glial unit; or the development of strategies for axonal and myelin repair that solve the issues of controlled differentiation, delivery and timing of these cell and growth factor-based interventions.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esclerosis Múltiple
Límite:
Humans
Idioma:
En
Revista:
Acta Neurol Scand Suppl
Año:
2006
Tipo del documento:
Article
País de afiliación:
Reino Unido
Pais de publicación:
DENMARK
/
DINAMARCA
/
DK