Melanocyte-marker-HMB-45 is regularly expressed in angiomyolipoma of the kidney.
Pathology
; 23(3): 185-8, 1991 Jul.
Article
en En
| MEDLINE
| ID: mdl-1664078
ABSTRACT
HMB-45 (melanocytic cell-specific monoclonal antibody) immunoreactivity was investigated in 10 cases of angiomyolipoma (AML) (1 with massive regional lymph node involvement) of the kidney and detected in all of them. No HMB-45 immunoreactivity was found in other tumors of the region which can occasionally be confused with AML, such as renal cell carcinoma, Wilms' tumor, and retroperitoneal sarcoma (leiomyosarcoma and liposarcoma). These findings indicate that HMB-45 is not a melanocyte-restricted marker and suggest that its expression might be useful in distinguishing AML from other tumors of the kidney and retroperitoneum.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Biomarcadores de Tumor
/
Hemangioma
/
Neoplasias Renales
/
Lipoma
/
Melanocitos
/
Anticuerpos Monoclonales
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Pathology
Año:
1991
Tipo del documento:
Article
País de afiliación:
Italia