Collagenase production in the exudate of a novel adjuvant-induced air pouch inflammation model in rats.
Agents Actions
; 34(1-2): 242-3, 1991 Sep.
Article
en En
| MEDLINE
| ID: mdl-1665296
ABSTRACT
To elucidate the role of collagenase in tissue destruction in chronic inflammation (e.g., in rheumatoid arthritis), we established a novel air pouch model in rats. Ten ml of air was injected subcutaneously on the dorsa of F344 rats, and 24 hours thereafter, Freund's complete adjuvant was injected into the air pouch. A remarkably high activity of trypsin-activated collagenase was detected dose-dependently in the pouch fluid at 8 days after the challenge injection. Concomitantly with the increase of collagenase activity, the weight of granuloma formed in the pouch decreased, suggesting that collagenase participates in the resorption of granuloma tissues.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Colagenasa Microbiana
/
Exudados y Transudados
/
Inflamación
Límite:
Animals
Idioma:
En
Revista:
Agents Actions
Año:
1991
Tipo del documento:
Article
País de afiliación:
Japón
Pais de publicación:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND