Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination.
Cell
; 125(3): 593-605, 2006 May 05.
Article
en En
| MEDLINE
| ID: mdl-16678101
ABSTRACT
While the biological roles of canonical Wnt/beta-catenin signaling in development and disease are well documented, understanding the molecular logic underlying the functionally distinct nuclear transcriptional programs mediating the diverse functions of beta-catenin remains a major challenge. Here, we report an unexpected strategy for beta-catenin-dependent regulation of cell-lineage determination based on interactions between beta-catenin and a specific homeodomain factor, Prop1, rather than Lef/Tcfs. beta-catenin acts as a binary switch to simultaneously activate expression of the critical lineage-determining transcription factor, Pit1, and to repress the gene encoding the lineage-inhibiting transcription factor, Hesx1, acting via TLE/Reptin/HDAC1 corepressor complexes. The strategy of functionally distinct actions of a homeodomain factor in response to Wnt signaling is suggested to be prototypic of a widely used mechanism for generating diverse cell types from pluripotent precursor cells in response to common signaling pathways during organogenesis.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transducción de Señal
/
Proteínas de Homeodominio
/
Linaje de la Célula
/
Proteínas Wnt
/
Beta Catenina
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos