Osteoporosis and osteosclerosis in sickle cell/beta-thalassemia: the role of the RANKL/osteoprotegerin axis.
Haematologica
; 91(6): 813-6, 2006 Jun.
Article
en En
| MEDLINE
| ID: mdl-16704959
ABSTRACT
Bone mineral density (BMD) was evaluated in 52 patients with HbS/beta-thalassemia. Seventeen (32%) patients had osteopenia/osteoporosis and 30 (57%) had osteosclerosis. Bone resorption was diminished in patients with osteosclerosis and increased in those with osteopenia/osteoporosis. The sRANKL/osteoprotegerin ratio was elevated in the osteosclerotic group. Osteoporosis patients had mild renal impairment and their BMD correlated with osteoprotegerin, and bone resorption markers. Osteosclerosis patients had multiple infarctions in the studied bones that led to reduced osteoclast activity and increased BMD. In conclusion, HbS/beta-thalassemia patients may develop osteopenia/osteoporosis mainly due to marrow expansion or osteosclerosis because of ischemia after a vaso-occlusive crisis. The RANKL/ osteoprotegerin axis participates in these phenomena.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteosclerosis
/
Osteoporosis
/
Glicoproteínas de Membrana
/
Proteínas Portadoras
/
Talasemia beta
/
Anemia de Células Falciformes
Límite:
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Haematologica
Año:
2006
Tipo del documento:
Article
País de afiliación:
Grecia