[Protective effect of lidocaine on injury alveolar Type II cells induced by LPS in adult rats].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
; 31(2): 241-4, 2006 Apr.
Article
en Zh
| MEDLINE
| ID: mdl-16706124
ABSTRACT
OBJECTIVE:
To investigate the effect of lidocaine on LPS induced apoptosis of cultured adult rat alveolar Type II (AT-II) cells.METHODS:
Cultured cells were exposed to LPS and lidocaine for 24 hours. Apoptosis and necrosis rates of cells were detected by flow cytometry and electron microscope. The activity of lactic dehydrogenase (LDH) was analyzed by using LDH kits.RESULTS:
LPS induced the AT-II cell injuries by increasing not only the necrosis and apoptosis rates but also the LDH release of cultured AT-II in vitro. Lidocaine decreased the necrosis and apoptosis rates of AT-II cells.CONCLUSION:
Lidocaine can directly inhibit the apoptosis and necrosis induced by LPS in cultured AT-II cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Alveolos Pulmonares
/
Apoptosis
/
Células Epiteliales
/
Lidocaína
Límite:
Animals
Idioma:
Zh
Revista:
Zhong Nan Da Xue Xue Bao Yi Xue Ban
Asunto de la revista:
MEDICINA
Año:
2006
Tipo del documento:
Article
País de afiliación:
China