Facile ring opening of 2,3-epoxy-steroids with aromatic amines in ionic liquids.
Steroids
; 71(8): 706-11, 2006 Aug.
Article
en En
| MEDLINE
| ID: mdl-16750547
ABSTRACT
Efficient ring opening of steroidal 2,3-epoxides with stoichiometric amount of aromatic amines has been carried out using an ionic liquid ([bmim](+)[BF(4)](-)) both as solvent and catalyst. The reactions were completely regio- and stereoselective in each case. The aminoalcohol products have chair conformations in ring A. The ionic liquid-mediated ring opening can efficiently be carried out with aliphatic amines like morpholine as well.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Solventes
/
Esteroides Heterocíclicos
/
Aminoácidos Aromáticos
/
Amino Alcoholes
/
Iones
Idioma:
En
Revista:
Steroids
Año:
2006
Tipo del documento:
Article
País de afiliación:
Hungria