[EGF binding site number of rat anterior pituitary is increased by chronic administration with dopaminergic agonist, CV 205-502]. / Le nombre de sites EGF de l'antéhypophyse du rat est augmenté par l'administration chronique de l'agoniste dopaminergique, le CV 205-502.
C R Acad Sci III
; 312(6): 241-5, 1991.
Article
en Fr
| MEDLINE
| ID: mdl-1675150
ABSTRACT
In order to assess whether a chronic treatment with a dopamine agonist, CV205-502, could modulate anterior pituitary epidermal growth factor (EGF) binding sites, female Wistar rats were treated or not (controls) with CV205-502 0.25 mg/kg/day sc for 8 days. This treatment significantly reduced rats' pituitary weight and plasma prolactin levels when compared to controls (weight 10.4 +/- 0.1 vs 11.1 +/- 0.1 mg, p less than 0.01; prolactin 1.2 +/- 0.2 vs 4.9 +/- 0.5 ng/ml, p less than 0.01). These decreases were associated with a significant stimulation of the number of pituitary EGF binding sites Bmax 16.7 +/- 2.3 vs 11.3 +/- 1.9 fmoles/mg proteins, p less than 0.01) with no significant effect on their affinity (Kd 0.94 +/- 0.17 vs 0.95 +/- 0.14 nM). Therefore, the modulation of pituitary EGF binding sites might be one of the mechanisms by which the dopamine agonist, CV205-502, exerts its pharmacological effects on hormonal secretions and/or cell multiplication in the pituitary.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Adenohipófisis
/
Dopaminérgicos
/
Factor de Crecimiento Epidérmico
/
Aminoquinolinas
Límite:
Animals
Idioma:
Fr
Revista:
C R Acad Sci III
Asunto de la revista:
BIOLOGIA
Año:
1991
Tipo del documento:
Article