No role of the dopamine transporter in acute ethanol effects on striatal dopamine dynamics.
Synapse
; 60(4): 288-94, 2006 Sep 15.
Article
en En
| MEDLINE
| ID: mdl-16786536
ABSTRACT
The acute effects of ethanol on dopamine (DA) release and clearance in the caudate-putamen were evaluated in wild-type and dopamine transporter (DAT) knockout (DAT-KO) mice, using microdialysis and voltammetry. Dialysate DA levels were elevated, approximately 80% above baseline levels, after administration of 2 g/kg ethanol in both wild-type and DAT-KO mice. In brain slices containing the caudate-putamen, a low (20 mM) concentration of ethanol produced no change in electrically stimulated DA release in either wild-type or DAT-KO mice. A high concentration (200 mM) of ethanol caused a similar decrease in DA release in slices from both types of mice. DA clearance was unaltered across the genotypes at low and high concentrations of ethanol. The fact that ethanol had similar effects in wild-type and DAT-KO mice, measured by in vivo microdialysis or brain slice voltammetry, supports the idea that acute ethanol does not interact with the DAT to produce its effects on the DA system.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dopamina
/
Depresores del Sistema Nervioso Central
/
Neostriado
/
Etanol
/
Proteínas de Transporte de Dopamina a través de la Membrana Plasmática
Límite:
Animals
Idioma:
En
Revista:
Synapse
Asunto de la revista:
NEUROLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos