Interaction between posaconazole and caspofungin in concomitant treatment of mice with systemic Aspergillus infection.

Cacciapuoti, Anthony; Halpern, Judith; Mendrick, Cara; Norris, Christine; Patel, Reena; Loebenberg, David

Cacciapuoti, Anthony; Halpern, Judith; Mendrick, Cara; Norris, Christine; Patel, Reena; Loebenberg, David.

Afiliación

Cacciapuoti A; Schering-Plough Research Institute, Kenilworth, NJ 07033, USA. anthony.cacciapuoti@spcorp.com

Antimicrob Agents Chemother ; 50(7): 2587-90, 2006 Jul.

Article en En | MEDLINE | ID: mdl-16801452

ABSTRACT

ABSTRACT

The interaction of posaconazole and caspofungin was evaluated in concomitant treatment of Aspergillus fumigatus (two strains) or A. flavus (one strain) systemic infections in immunocompetent mice. Survival curves for mice treated with the combinations were compared statistically with those for mice treated with the component monotherapies. No antagonism was observed.

Asunto(s)

Antifúngicos/uso terapéutico; Aspergilosis/tratamiento farmacológico; Aspergillus flavus/efectos de los fármacos; Aspergillus fumigatus/efectos de los fármacos; Péptidos Cíclicos/uso terapéutico; Triazoles/uso terapéutico; Animales; Aspergilosis/microbiología; Caspofungina; Interacciones Farmacológicas; Quimioterapia Combinada; Equinocandinas; Lipopéptidos; Masculino; Ratones; Pruebas de Sensibilidad Microbiana

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Péptidos Cíclicos / Aspergilosis / Aspergillus flavus / Aspergillus fumigatus / Triazoles / Antifúngicos Límite: Animals Idioma: En Revista: Antimicrob Agents Chemother Año: 2006 Tipo del documento: Article País de afiliación: Estados Unidos

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