The intradermal Leishmanin reaction induces antigen-specific maturation of canine dendritic cells with up-regulation of MHCII synthesis and expression.
J Comp Pathol
; 135(1): 17-24, 2006 Jul.
Article
en En
| MEDLINE
| ID: mdl-16814802
ABSTRACT
Dendritic cells (DCs) are professional antigen-presenting cells that reside in many tissues, including the skin. This study showed that intradermal injection of leishmanin in Leishmania infantum-infected dogs induced the "up-regulation" of surface MHCII expression, associated with progressive ultrastrucutural changes characteristic of DC maturation, including the formation of multilaminar MHC class II-containing compartments and arrays of tubulo-vesicular structures. These changes were not observed in control dogs from L. infantum non-endemic areas. The results indicated that canine DCs were effector cells in delayed-type hypersensitivity, that the leishmanin reaction was specific for a cell-mediated reaction to L. infantum in infected dogs, and that canine DCs possessed ultrastructural organelles reminiscent of those in activated human DCs.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Células Dendríticas
/
Antígenos de Histocompatibilidad Clase II
/
Antígenos
/
Antígenos de Protozoos
Límite:
Animals
Idioma:
En
Revista:
J Comp Pathol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Italia