Prostacyclin synthesis in relation to sympathoadrenal activation. Effects of beta-blockade.
Circulation
; 84(6 Suppl): VI38-43, 1991 Dec.
Article
en En
| MEDLINE
| ID: mdl-1683609
ABSTRACT
Results from several studies suggest that beta-adrenoceptor blockade causes increased biosynthesis of the vasodilator prostanoid prostacyclin in the arterial wall. This effect may contribute to the clinical effects of beta-blockers in hypertension and coronary heart disease. Studies in hypertensive patients and in animals indicate that the arterial pressure reduction after beta-blockade is related to the associated increase of prostacyclin biosynthesis, regarding both magnitude and time of onset of effect. Some observations suggest that the effects of beta-blockers in myocardial ischemia may in part be due to an improvement of coronary blood flow caused by increased prostacyclin biosynthesis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Sistema Nervioso Simpático
/
Epoprostenol
/
Antagonistas Adrenérgicos beta
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Circulation
Año:
1991
Tipo del documento:
Article
País de afiliación:
Suecia