The rggC locus, with a frameshift mutation, is involved in oxidative stress response by Streptococcus thermophilus.
Arch Microbiol
; 186(3): 161-9, 2006 Sep.
Article
en En
| MEDLINE
| ID: mdl-16847652
ABSTRACT
In Streptococcus thermophilus, the locus rggC contains a frameshift mutation and thus consists of two open reading frames (ORFs), rggC (1) and rggC (2), which encode proteins exhibiting similarity with the Rgg transcriptional regulator family. In this work, mutants showing a partial deletion of rggC (1) and rggC (2 )were constructed and their response to menadione, a superoxide-generating compound, was analysed. These mutants exhibited different behaviour to this oxidative stress compared with the wild-type strain. Analysis of this locus among 21 strains of S. thermophilus showed a polythymine tract length variability and a strain-dependant adenine residue could be found upstream of this repeat. This interstrain polymorphism supports evidence for the hypothesis that the rggC locus is phase variable.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Bacterianas
/
Transactivadores
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Mutación del Sistema de Lectura
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Estrés Oxidativo
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Streptococcus thermophilus
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Proteínas de Unión al ADN
Idioma:
En
Revista:
Arch Microbiol
Año:
2006
Tipo del documento:
Article
País de afiliación:
Francia