Cyclic GMP phosphodiesterase activity role in normal and inflamed human dental pulp.
Int J Immunopathol Pharmacol
; 17(3 Suppl): 21-4, 2004.
Article
en En
| MEDLINE
| ID: mdl-16857102
ABSTRACT
Cyclic GMP phosphodiesterase (cGMP PDE) plays an important role in pulp tissues. High levels of cGMP PDE are found in dental pulp cells. In the present study cGMP PDE activity was analyzed in normal healthy human dental pulps, in reversible pulpitis and in irreversible pulpitis. Enzymatic cGMP PDE control values for normal healthy pulps were 4.74+/-0.32 nmol/mg of proteins. In reversible pulpitis the cGMP PDE activity increased almost 3 times. In irreversible pulpitis specimens the values increased 4.5 times compared with the normal healthy pulps activity. The differences between the groups (control vs. reversible pulpitis and vs. irreversible pulpitis) were statistically significant. These results point to a role of cGMP PDE in the initial pulp response after injury.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pulpitis
/
3',5'-GMP Cíclico Fosfodiesterasas
/
Pulpa Dental
Límite:
Humans
Idioma:
En
Revista:
Int J Immunopathol Pharmacol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
FARMACOLOGIA
/
PATOLOGIA
Año:
2004
Tipo del documento:
Article
País de afiliación:
Italia