Voltage-activated currents in the CRI-G1 rat insulin-secreting cell-line.
Comp Biochem Physiol A Comp Physiol
; 100(3): 613-21, 1991.
Article
en En
| MEDLINE
| ID: mdl-1685973
1. The whole-cell configuration of the patch-clamp recording technique was used to characterize the electrophysiological properties of CRI-G1 insulin-secreting cells. 2. Current-clamp recordings demonstrated the excitable nature of these cells. 3. Voltage-clamp recordings revealed the presence of an inward Na+ current, an inward Ca2+ current and a delayed outward K+ conductance. 4. The electrophysiological properties of CRI-G1 closely resemble those of pancreatic beta-cells, thereby rendering this cell-line as a useful alternative to freshly isolated cells for the study of pancreatic beta-cell electrophysiology and pharmacology.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Islotes Pancreáticos
/
Insulina
Límite:
Animals
Idioma:
En
Revista:
Comp Biochem Physiol A Comp Physiol
Año:
1991
Tipo del documento:
Article
Pais de publicación:
Reino Unido