Cross-talk between APC/C and CBP/p300.
Cancer Biol Ther
; 5(7): 760-2, 2006 Jul.
Article
en En
| MEDLINE
| ID: mdl-16861917
ABSTRACT
APC/C complex has been known to regulate cell cycle progression via its ubiquitin E3 ligase activity that targets a number of cell cycle regulators. In a recent report, it is shown that APC/C interacts with transcription co-activators, CBP and p300, via its APC5 and APC7 subunits. The authors further demonstrate the functional significance of APC/C-CBP/p300 interaction in regulating both transcription and cell cycle progression. These findings have profound implications in unveiling additional functions and regulatory mechanisms of these two seemingly independent molecular modulators.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Transformación Celular Neoplásica
/
Transformación Celular Viral
/
Regulación de la Expresión Génica
/
Complejos de Ubiquitina-Proteína Ligasa
/
Factores de Transcripción p300-CBP
Límite:
Humans
Idioma:
En
Revista:
Cancer Biol Ther
Asunto de la revista:
NEOPLASIAS
/
TERAPEUTICA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos