Trisomy 1q in a patient with severe aplastic anemia.
Cancer Genet Cytogenet
; 169(1): 73-5, 2006 Aug.
Article
en En
| MEDLINE
| ID: mdl-16875941
ABSTRACT
Aplastic anemia is a rare, serious disease characterized by hypocellular bone marrow and pancytopenia in the peripheral blood. Most cases are acquired, idiopathic, and without gross cytogenetic abnormalities. A few chromosome abnormalities have recurred among a small subset of patients, most commonly trisomy 8 and monosomy 7. Some of these chromosome abnormalities have prognostic and therapeutic significance, although for most the clinical relevance is not known. We present the case of a 40-year-old man with idiopathic severe aplastic anemia in bone marrow cells with trisomy of the whole long arm of chromosome 1 due to an unbalanced translocation between chromosomes 1 and 15 at breakpoints of q10 and 15q10. This clonal abnormality (which, to our knowledge, has not been previously reported in a patient with aplastic anemia) suggests that genes on 1q may be involved in marrow aplasia.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trisomía
/
Cromosomas Humanos Par 1
/
Anemia Aplásica
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Cancer Genet Cytogenet
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos