Localization of small heterodimer partner (SHP) and secretin in mouse duodenal cells.
Ann N Y Acad Sci
; 1070: 371-5, 2006 Jul.
Article
en En
| MEDLINE
| ID: mdl-16888194
ABSTRACT
Previous studies have demonstrated the transcriptional repressive property of the atypical nuclear receptor, small heterodimer partner (SHP), on NeuroD. NeuroD is a basic helix-loop-helix transcription factor that has also been shown to be important in modulating secretin gene expression. The present study revealed the activation of the human secretin core promotor by overexpressing NeuroD, and the localization of SHP and secretin-producing cells in mouse duodenal epithelium by immunohistochemical stainings. These results indicated that SHP and secretin are potentially co-expressed and lead us to propose a novel regulatory pathway, in which SHP represses NeuroD's positive regulatory activity on secretin gene.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Secretina
/
Receptores Citoplasmáticos y Nucleares
/
Duodeno
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Ann N Y Acad Sci
Año:
2006
Tipo del documento:
Article