Expediting drug discovery: recent advances in fast medicinal chemistry--optimization of hits and leads.
Curr Opin Drug Discov Devel
; 9(4): 425-44, 2006 Jul.
Article
en En
| MEDLINE
| ID: mdl-16889227
ABSTRACT
This article reviews the literature from January 2004 to January 2006 relating to the use of parallel chemistry compound libraries in drug discovery. Examples of libraries that have yielded active compounds across a range of biological targets are presented, together with synthetic details where relevant. The background of the biological target, and any structure-activity relationship that can be discerned from members of a library series, are also commented upon. A brief discussion of new technological developments in library design and synthesis, and likely future directions for parallel chemistry in the context of drug discovery, is also presented.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Preparaciones Farmacéuticas
/
Química Farmacéutica
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Curr Opin Drug Discov Devel
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2006
Tipo del documento:
Article
País de afiliación:
Bélgica