Is serum gentamicin level a good predictor of graft injury in intestinal transplantation?
Transplant Proc
; 38(6): 1733-4, 2006.
Article
en En
| MEDLINE
| ID: mdl-16908265
ABSTRACT
INTRODUCTION:
Following intestinal transplant (SBT), the early diagnosis and treatment of rejection is a major management aim. The diagnosis of rejection is based on histology of stomal biopsies. Oral gentamycin (2.5 mg/kg) was used for selective decontamination of the digestive system. Our hypothesis was that gentamycin might be absorbed in the presence of graft dysfunction.AIM:
Our goal was to assess the correlation between serum gentamycin level and the health of the intestinal graft. SUBJECTS ANDMETHODS:
Among 33 SBT performed from 1993 to 2005, serum gentamycin levels were performed once weekly or more often when there was a suspicion of rejection. All data were analyzed retrospectively.RESULTS:
Adequate trough levels were achieved for only 23 patients, six of whom had histologically proven rejection and only one did not have a raised gentamycin content. Five patients with raised levels but no rejection included two with severe intestinal ischemia and three with bowel obstruction/ileus. Four of the five patients required laparotomies.CONCLUSION:
We concluded that in our study raised serum gentamycin levels were a good predictor of rejection or significant injury to the graft.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trasplante Homólogo
/
Gentamicinas
/
Biomarcadores
/
Rechazo de Injerto
/
Intestino Delgado
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Límite:
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Transplant Proc
Año:
2006
Tipo del documento:
Article
País de afiliación:
Reino Unido