Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.
Am J Hum Genet
; 79(3): 586-92, 2006 Sep.
Article
en En
| MEDLINE
| ID: mdl-16909399
ABSTRACT
Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esquizofrenia
/
Estrés Oxidativo
/
Predisposición Genética a la Enfermedad
/
Glutamato-Cisteína Ligasa
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Am J Hum Genet
Año:
2006
Tipo del documento:
Article
País de afiliación:
Suiza