Polyribonucleotide-anthraquinone interactions: in vitro antiviral activity studies.
Cell Biol Int Rep
; 14(3): 219-28, 1990 Mar.
Article
en En
| MEDLINE
| ID: mdl-1693102
ABSTRACT
Twelve anthraquinones (AQ) were evaluated for their ability to potentiate the antiviral activity of poly r(A-U) using a human foreskin fibroblast-vesicular stomatitis virus bioassay in which the AQ was combined with 0.2 mM poly r(A-U) to produce an AQ/ribonucleotide ratio of 1/4. Poly r(A-U) and the AQ alone were not effective antiviral agents. Five of the twelve AQs tested, mitoxantrone, adriamycin, ametantrone, carminic acid and daunomycin, enhanced the antiviral activity of poly r(A-U) 9- to 13-fold. The interferon-inducing activity of the five active AQ/poly r(A-U) combinations was equal to the sum of the interferon-inducing activities of their constituents. These five AQs appear to potentiate the antiviral activity of poly r(A-U) without superinduction of interferon.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Antivirales
/
Antraquinonas
/
Poli A-U
Límite:
Humans
Idioma:
En
Revista:
Cell Biol Int Rep
Año:
1990
Tipo del documento:
Article