12-lipoxygenase products are potent inhibitors of prostacyclin-induced renin release.
Proc Soc Exp Biol Med
; 194(3): 224-30, 1990 Jul.
Article
en En
| MEDLINE
| ID: mdl-1694030
ABSTRACT
In isolated human or rat glomeruli, arachidonic acid can be metabolized by the cyclooxygenase pathway to prostaglandins or by the lipoxygenase pathway to hydroxyeicosatetraenoic acids (HETES). We have recently shown that 12-lipoxygenase products are potent inhibitors of renin release. Since prostacyclin (PGI2) is a potential renin secretagogue, we studied the direct effects of 12-lipoxygenase products on prostacyclin-induced renin secretion. Treatment of rat renal cortical slices with picomolar concentrations of 12-hydroperoxyeicosatetraenoic acid (12-HPETE) and 12-HETE blocked the prostacyclin- or iloprost (an analog of PGI2)-induced renin secretion. The inhibitory effects of 12-lipoxygenase products were not exhibited by the 5-lipoxygenase-derived products, leukotriene B4 and 5-HPETE. These results suggest that HETES are not only potent modulators of prostacyclin actions on renin, but that the concerted actions of these compounds in cells may be critical determinants of the juxtaglomerular cell secretion of renin.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Hidroxieicosatetraenoicos
/
Leucotrienos
/
Epoprostenol
/
Renina
/
Corteza Renal
Límite:
Animals
Idioma:
En
Revista:
Proc Soc Exp Biol Med
Año:
1990
Tipo del documento:
Article