[Pathophysiology and pathomorphology of osteoporosis]. / Pathophysiologie und Pathomorphologie der Osteoporose.
Radiologe
; 46(10): 831-8, 2006 Oct.
Article
en De
| MEDLINE
| ID: mdl-16964480
ABSTRACT
Osteoporosis is a disease that leads to fragility fractures due to loss of bone mass and bone microstructure. This review presents an update on the fundamental pathophysiologic and pathomorphologic mechanisms of bone loss situations. Pathomorphologic characteristics such as perforations and microcallus formations are explained. The physiologic relevance of the remodeling process as well as its control by local-paracrine, systemic-endocrine and central-neural signaling pathways is discussed. Furthermore the role of hormones such as estrogen, FSH and leptin, of transcription-factors such as Runx2 and osterix and as well as that of the wnt signaling pathway for bone cell differentiation and function is presented. On the basis of current knowledge osteoporosis can be diagnosed, treated and fractures can be prevented. However, it is likely that new and even more effective diagnostic and therapeutic strategies will emerge as our understanding of the remodeling process that controls osteoblast and osteoclast function increases.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Osteoporosis
/
Huesos
/
Resorción Ósea
/
Calcificación Fisiológica
/
Hormona del Crecimiento
/
Fracturas Espontáneas
/
Modelos Biológicos
Tipo de estudio:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
Límite:
Humans
Idioma:
De
Revista:
Radiologe
Año:
2006
Tipo del documento:
Article