The relevance of RT-PCR detection of disseminated tumour cells is hampered by the expression of markers regarded as tumour-specific in activated lymphocytes.
Eur J Cancer
; 42(16): 2671-4, 2006 Nov.
Article
en En
| MEDLINE
| ID: mdl-16978860
Marker genes, commonly used to detect circulating tumour cells in RT-PCR-based tests: squamous-cell carcinoma antigen, epidermal growth factor receptor, mammaglobin, small breast epithelial mucin, but not carbonic anhydrase 9, were shown to be expressed in normal, mitogen-stimulated peripheral blood mononuclear cells (PBMNC). Thus, considering the inflammatory reactions often accompanying cancer development, to reduce false-positive results of the metastatic tumour cell tests, molecular markers should be validated not against normal peripheral blood, but against activated lymphoid cells, such as in vitro mitogen-stimulated PBMNC.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucocitos Mononucleares
/
Activación de Linfocitos
/
Biomarcadores de Tumor
/
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
/
Células Neoplásicas Circulantes
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Eur J Cancer
Año:
2006
Tipo del documento:
Article
País de afiliación:
Polonia
Pais de publicación:
Reino Unido