From systems biology to dynamical neuropharmacology: proposal for a new methodology.
Syst Biol (Stevenage)
; 153(4): 299-308, 2006 Jul.
Article
en En
| MEDLINE
| ID: mdl-16986631
ABSTRACT
The concepts and methods of systems biology are extended to neuropharmacology in order to test and design drugs for the treatment of neurological and psychiatric disorders. Computational modelling by integrating compartmental neural modelling techniques and detailed kinetic descriptions of pharmacological modulation of transmitter-receptor interaction is offered as a method to test the electrophysiological and behavioural effects of putative drugs. Even more, an inverse method is suggested as a method for controlling a neural system to realise a prescribed temporal pattern. In particular, as an application of the proposed new methodology, a computational platform is offered to analyse the generation and pharmacological modulation of theta rhythm related to anxiety.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neurofarmacología
/
Receptores de Neurotransmisores
/
Transmisión Sináptica
/
Neurotransmisores
/
Biología de Sistemas
/
Neuronas
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Syst Biol (Stevenage)
Asunto de la revista:
BIOLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Estados Unidos