Risk factors for intussusception in infants in Vietnam and Australia: adenovirus implicated, but not rotavirus.
J Pediatr
; 149(4): 452-60, 2006 Oct.
Article
en En
| MEDLINE
| ID: mdl-17011313
ABSTRACT
OBJECTIVE:
This study aimed to investigate risk factors for the development of intussusception in infants in a developing country with a suspected high incidence and in a developed country with a low incidence. STUDYDESIGN:
A prospective case-control study of infants <2 years of age with idiopathic intussusception confirmed by air enema or surgery was conducted at the National Hospital of Paediatrics (NHP), Vietnam (n = 533) and the Royal Children's Hospital (RCH), Australia (n = 51). Diagnosis was validated in a subset (84% NHP; 67% RCH) by an independent blinded radiologist. Risk factor assessment was performed using a standardized questionnaire. Stool specimens were assayed for bacterial, viral, and parasitic agents.RESULTS:
The incidence of intussusception in Vietnam was 302/100,000 in infants <1 year of age (95% CI 258-352), substantially higher than in Australia (71/100,000). A strong association with adenovirus infection was observed at both sites (cases positive at NHP 34%, OR 8.2; cases positive at RCH 40%, OR 44). No association was identified between intussusception and rotavirus, other enteric pathogens, oral polio vaccine, feeding practices, or living conditions.CONCLUSIONS:
The incidence of intussusception in infants was markedly higher in Vietnam than in Australia. A strong association between adenovirus infection and intussusception was identified at both sites suggesting that adenovirus may play a role in the etiology of intussusception.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones por Adenovirus Humanos
/
Intususcepción
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
/
Infant
/
Male
País/Región como asunto:
Asia
/
Oceania
Idioma:
En
Revista:
J Pediatr
Año:
2006
Tipo del documento:
Article
País de afiliación:
Australia