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Immunization of mice with antibiotic-treated Escherichia coli results in enhanced protection against challenge with homologous and heterologous bacteria.
Raponi, G; Keller, N; Overbeek, B P; Rozenberg-Arska, M; Torensma, R; Verhoef, J.
Afiliación
  • Raponi G; Eijkman-Winkler Laboratory for Medical Microbiology, University Hospital of Utrecht, Netherlands.
J Infect Dis ; 163(1): 122-7, 1991 Jan.
Article en En | MEDLINE | ID: mdl-1701816
ABSTRACT
The murine immune response to Escherichia coli exposed to subminimal inhibitory concentrations of four antibiotics was investigated. Groups of mice were injected for 8 weeks with formalin-killed bacteria and subsequently challenged with 10 x LD50 of viable E. coli. Mice receiving saline only (controls) died within 24 h. The mortality of mice immunized with ciprofloxacin-treated E. coli was significantly lower than that of mice immunized with E. coli untreated or treated with other antibiotics. Sera from mice immunized with ciprofloxacin-treated bacteria showed better bacteriostatic capacity and enhanced production of antibodies that bound to homologous and heterologous lipopolysaccharide isolated from several smooth and rough gram-negative strains. The better protection observed in mice immunized with ciprofloxacin-treated E. coli was probably due to an enhanced production of antibodies to epitopes on lipopolysaccharide that became better exposed and so more accessible after treatment with ciprofloxacin.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunización / Escherichia coli / Infecciones por Escherichia coli / Antibacterianos Límite: Animals Idioma: En Revista: J Infect Dis Año: 1991 Tipo del documento: Article País de afiliación: Países Bajos
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunización / Escherichia coli / Infecciones por Escherichia coli / Antibacterianos Límite: Animals Idioma: En Revista: J Infect Dis Año: 1991 Tipo del documento: Article País de afiliación: Países Bajos