Immunization of mice with antibiotic-treated Escherichia coli results in enhanced protection against challenge with homologous and heterologous bacteria.
J Infect Dis
; 163(1): 122-7, 1991 Jan.
Article
en En
| MEDLINE
| ID: mdl-1701816
ABSTRACT
The murine immune response to Escherichia coli exposed to subminimal inhibitory concentrations of four antibiotics was investigated. Groups of mice were injected for 8 weeks with formalin-killed bacteria and subsequently challenged with 10 x LD50 of viable E. coli. Mice receiving saline only (controls) died within 24 h. The mortality of mice immunized with ciprofloxacin-treated E. coli was significantly lower than that of mice immunized with E. coli untreated or treated with other antibiotics. Sera from mice immunized with ciprofloxacin-treated bacteria showed better bacteriostatic capacity and enhanced production of antibodies that bound to homologous and heterologous lipopolysaccharide isolated from several smooth and rough gram-negative strains. The better protection observed in mice immunized with ciprofloxacin-treated E. coli was probably due to an enhanced production of antibodies to epitopes on lipopolysaccharide that became better exposed and so more accessible after treatment with ciprofloxacin.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunización
/
Escherichia coli
/
Infecciones por Escherichia coli
/
Antibacterianos
Límite:
Animals
Idioma:
En
Revista:
J Infect Dis
Año:
1991
Tipo del documento:
Article
País de afiliación:
Países Bajos