Study of the clinical usefulness of a dental drug system for selective reduction of mutans streptococci using a case series.
J Oral Sci
; 48(3): 111-6, 2006 Sep.
Article
en En
| MEDLINE
| ID: mdl-17023742
ABSTRACT
The aim of this study was to evaluate the clinical efficacy and safety of a dental drug delivery system (3DS) for the selective reduction of mutans streptococci. Twenty patients with high levels of mutans streptococci in saliva participated. The efficacy of 0.2% chlorhexidine (CHX) delivered by 3DS in reducing the salivary levels of mutans streptococci compared with total streptococci and lactobacilli was investigated. Each subject was treated by professional mechanical tooth cleaning (PMTC) and subsequently individual trays with CHX for 5 min. Salivary bacterial samples were taken at the baseline and weeks 1-12. A significant reduction in the colony count of mutans streptococci was observed during the first 4 weeks compared with the baseline count, while no significant decrease in the count of total streptococci or lactobacilli was found during 12 weeks. In particular, the proportion of mutans streptococci in total streptococci remained low after 12 weeks. Our results indicate that the new 3DS used in combination with PMTC appears to be a promising intraoral drug delivery system which, when used with a low CHX concentration selectively, effectively reduces mutans streptococci in the oral cavity with no adverse effects.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Saliva
/
Streptococcus mutans
/
Clorhexidina
/
Sistemas de Liberación de Medicamentos
/
Antiinfecciosos Locales
Tipo de estudio:
Evaluation_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Oral Sci
Asunto de la revista:
ODONTOLOGIA
Año:
2006
Tipo del documento:
Article
País de afiliación:
Japón