Histopathological evidence of antagonistic effects of tributyltin on benzo[a]pyrene toxicity in the Arctic charr (Salvelinus alpinus).
Sci Total Environ
; 372(2-3): 549-53, 2007 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-17126381
ABSTRACT
We previously reported that long-term (54 days), repeated intraperitoneal exposure to low doses of tributyltin (TBT; 0.3 mg/kg) inhibited the metabolic activation of co-administered benzo[a]pyrene (BaP; 3 mg/kg) in the Arctic charr (Salvelinus alpinus); BaP, in turn, stimulated the metabolism and/or excretion of TBT. Here, we report the results of histopathological examinations of liver, kidney and pseudobranch tissue samples originating from these same fish. The results revealed higher lesion incidences at all sampling time points (Days 8, 32 and 56) among BaP-exposed fish compared with fish exposed to either TBT alone or combined with BaP. The severity of lesions like necrosis was also higher in BaP-exposed fish. Moreover, hepatic basophilic foci were observed exclusively in fish exposed to BaP alone. Together, these results provide new evidences that TBT can antagonize BaP toxicity in fish exposed to both pollutants under controlled laboratory conditions. In contrast, BaP does not appear to provide protection against TBT toxicity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos de Trialquiltina
/
Trucha
/
Benzo(a)pireno
/
Riñón
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
Sci Total Environ
Año:
2007
Tipo del documento:
Article
País de afiliación:
Brasil